We introduce our new TDI Kernel v1.0 to the public domain.

Open source drug discovery has so far remained elusive with few exceptions. We argue that the stumbling block has been the absence of a critical mass of preexisting work that volunteers can improve through a series of granular contributions. Historically, open source software collaborations have almost never succeeded without such “kernels”. Here we introduce the results from a newly assembled computational pipeline for identifying protein targets for drug discovery in ten organisms that cause tropical diseases. We have also experimentally tested two promising targets for their binding to commercially available drugs. The resulting kernel provides a base of potential drug targets and lead candidates around which an on-line open source community can nucleate. We invite viewers to donate their judgment and in silico and in vitro experiments to develop these targets to the point where drug optimization can begin. 

Please, visit the TDI’s kernel site by clicking at the upper-right corner of this page.

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• BROWSE / IN kernel News
• « New look for the tropicaldisease.org
• » 2008 Target Competition for Neglected Diseases (UC Berkeley)