Structural Genomics @CNAG CRG

How biomolecules fold and function in a three-dimensional space is one of the most challenging questions in biology. For example, we have limited knowledge on how the 2-meter-long DNA molecule folds in the micro-sized nucleus or how RNA, proteins and small chemical compounds fold and interact to perform their most basic functions of the cell.

Our research group employ the laws of physics and the rules of evolution to develop and apply computational methods for predicting the 3D structures of macromolecules and their complexes. In particular, we study the following macromolecules:

DNA · RNA · Proteins

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