Structure determination of genomes.More recently, we have engaged collaboration with experimentalists to study the 3D organization of the chromatin. Such work is resulting in the first ever structures of genomic domains and entire genomes. This work has been funded by a HFSP Research Grant, the European Research Council and the Spanish Ministerio de Economia y Competitividad. |
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Comparative RNA structure prediction.The recent interest in RNA, specially non-coding RNA molecules, has prompted us to develop a series of tools for the alignment of RNA structures and the prediction of their functions. This work was funded by a Marie Curie action, a Generalitat Valenciana research grant and the Spanish Ministerio de Ciencia e Innovación. |
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Protein-Ligand interactions.We develop methods for comparative docking of small chemical compounds and their target proteins. Such methods have already been applied to identify drug targets in ten genomes that cause tropical diseases. This work was part of the Tropical Disease Initiative and was funded by the Spanish Ministerio de Ciencia e Innovación. |
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