Structural Genomics @CNAG ˇ CRG
Proteins (2006-2012) Line closed!
We have been pioneers in applying computational methods within an open source framework. In 2004, while I was Assistant Adj. Professor at UCSF, I co-initiated the Tropical Disease Initiative (TDI) with the aim of finding cures for tropical diseases such as malaria, leishmaniasis, denge, or tuberculosis. The main idea behind TDI is to promote research in a decentralized, Web-based, community-wide effort where scientists from laboratories, universities, institutes, and corporations can work together for a common cause. TDI provides, in our opinion, a perfect venue where our research can be tested and applied with immediate repercussion and publicity. Our inmediate aim is to continue applying our protein structure prediction methods to study neglected diseases.Selected articles
| Martínez-Jiménez, F., Overington, J.P., Al-Lazikani, B. and Marti-Renom, M.A. | ||
| "Rational design of non-resistant targeted cancer therapies." | ||
| Scientific Reports (2017) 7 46632 | ||
| Baeza-Delgado, C., Von Heijne, G., Marti-Renom, M.A. and Mingarro, I. | ||
| "Biological insertion of computationally designed short transmembrane segments." | ||
| Scientific Reports (2016) 6 23397 | ||
| Martínez-Jiménez, F. and Marti-Renom, M.A. | ||
| "Ligand-target prediction by structural network biology using nAnnoLyze." | ||
| PLOS Computational Biology (2015) 11(3) e1004157 | ||
| Martínez-Jiménez, F., Papadatos, G., Yang, L., Wallace, I.M., Kumar, V., Pieper, U., Sali, A., Brown, J.R., Overington, J.P. and Marti-Renom, M.A. | ||
| "Target prediction for an open access set of compounds active against Mycobacterium tuberculosis" | ||
| PLOS Computational Biology (2013) 9(10) e1003253 | ||
| Köser, C.U., Bryant, J.M., Becq, J., Török, M.E., Ellington, M.J., Marti-Renom, M.A., Carmichael, A.J., Parkhill, J., Smith, G.P. and Peacock, S.J. | ||
| "Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis" | ||
| NEJM (2013) 369 290-292 | ||
Grants
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European Union. ERA-NET Pathogenomics. 2011-2014 [PIM2010EPA-00719]. A genome-wide approach for characterizing the mode of action of novel compounds against Tuberculosis (GeMoA). |
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Spain. MICINN. Plan Nacional. 2011-2014 [BFU2010-19310]. Structural bioinformatics for drug discovery against organisms causing neglected tropical diseases. |
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Valencia. Complementary Grant. 2011-2011 [ACOMP/2011/048]. Structural bioinformatics for drug discovery against organisms causing neglected tropical diseases. |
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Valencia. Complementary Grant. 2009-2009 [ACOMP/2009/007]. Comparative docking of proteins and small molecules. |
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European Union. 6th Framework Programme. 2007-2010 [STREP018830]. Chemical Genomics by Activity Monitoring of Proteases. |
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Spain. MEC. Plan Nacional. 2007-2010 [BIO2007-66670]. Comparative docking of proteins and small molecules. |